Vipera Aspis Snake Venom

Vipera Aspis Snake Venom


Buy Vipera aspis Venom Online, can be found in NE Spain, France, Switzerland, Germany, Italy, Slovenia. According to WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins, the Vipera aspis species is of highest medical importance in Western Europe.

The venom of Vipera aspis is used for the production of antivenom immunoglobulins aimed at these countries.
The venom of Vipera aspis is also used in homeopathic remedies (Vipera redi)

Vaspins A, B (PLA² inhibitors) Ammodytins I1, I2, svVEGF Toxin HF, PLA² II and III are extracted from the venom of Vipera aspis.

For Research purposes: the venom of Vipera aspis is expected to contain Neurotoxins, Procoagulants and Haemorrhagins.

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Buy Vipera Aspis Venom Online in USA.The variation of venom composition with geography is an important aspect of intraspecific variability in the Vipera genus, although causes of this variability remain unclear. The diversity of snake venom is important both for our understanding of venomous snake evolution and for the preparation of relevant antivenoms to treat envenomations.
Methodology/Principal Find

We conduct an epidemiological survey of snake bite in various regions of France. In parallel, we carry out the analysis of the genes and the transcripts encoding venom PLA2s. We used SELDI technology to study the diversity of PLA2 in various venom sample. Neurological signs (mainly cranial nerve disturbances) were report after snake bites in three regions of France: Languedoc-Roussillon, Midi-Pyrénées and Provence-Alpes-Côte d’Azur. Genomes of Vipera aspis snakes from south-east France were show to contain ammodytoxin isoforms never describ in the genome of Vipera aspis from other French regions. Surprisingly, transcript encoding venom neurotoxic PLA2s is find in snakes of Massif Central region. Accordingly, SELDI analysis of PLA2 venom composition confirm the existence of population of neurotoxic Vipera aspis snakes in the west part of the Massif Central mountains.


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Conclusions/SignificanceThe association of epidemiological studies to genetic, biochemical and immunochemical analyses of snake venoms allow a good evaluation of the potential neurotoxicity of snake bites. A correlation was find between the expression of neurological symptoms in humans and the intensity of the cross-reaction of venoms with anti-ammodytoxin antibodies, which is correlate with the level of neurotoxin (vaspin and/or ammodytoxin) expression in the venom. The origin of the two recently identify neurotoxic snake populations is discusse according to venom PLA2 genome and transcriptome data.

Four species of vipers of the Vipera genus live in mainland France. Two of these species have not been implicated in causing serious envenomation.


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Snake venoms are complex mixtures of biologically active proteins. Diversity of snake venom within species has repeatedly been described over the last twenty years. Interspecies hybridization may be a major mechanism of diversification of the composition of snake venoms.




Three species of venomous snakes are of medical importance in Europe: Vipera aspis, Vipera berus and Vipera ammodytes (Vam). The clinical features of Vipera aspis aspis (Vaa) and Vipera berus berus (Vbb) envenomations are mostly local,

but can be associated with systemic signs (gastrointestinal and coagulation disorders, low blood pressure) in cases of severe envenomation.
2. Composition of Vipera aspis Venom and Circumstances Related to Envenomation

The venoms of Vipera aspis and Vipera berus present similar compositions [1]. Both contain kininogenase (hypotensive bradykinin-releasing enzyme), prothrombin-activating factors, proteases, and hyaluronidases. Neurotoxins of the phospholipase A2 type have been

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